Regulation of Lymphatic GM-CSF Expression by the E3 Ubiquitin Ligase Cbl-b

Regulation of Lymphatic GM-CSF Expression by the E3 Ubiquitin Ligase Cbl-b

Genome-wide association studies as well as lymphatic expression analyses have linked both Cbl-b and GM-CSF to human multiple sclerosis as well as other autoimmune diseases. Both Cbl-b and GM-CSF have been shown to play a prominent role in the development of murine encephalomyelitis; however, no func...

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Bibliographic Details
Main Authors: Sebastian Peer, Giuseppe Cappellano, Natascha Hermann-Kleiter, Karin Albrecht-Schgoer, Reinhard Hinterleitner, Gottfried Baier, Thomas Gruber
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Immunology
Subjects:
adaptive immunity
multiple sclerosis
experimental autoimmune encephalomyelitis
Cbl-b
GM-CSF
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02311/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02311/full

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