Downregulation of Fat Mass and Obesity Associated (FTO) Promotes the Progression of Intrahepatic Cholangiocarcinoma

Downregulation of Fat Mass and Obesity Associated (FTO) Promotes the Progression of Intrahepatic Cholangiocarcinoma

Intrahepatic cholangiocarcinoma (ICC) ranks as the second most malignant type of primary liver cancer with a high degree of incidence and a very poor prognosis. Fat mass and obesity-associated protein (FTO) functions as an eraser of the RNA m6A modification, but its roles in ICC tumorigenesis and de...

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Bibliographic Details
Main Authors: Zhuo-Xian Rong, Zhi Li, Jun-Ju He, Li-Yu Liu, Xin-Xin Ren, Jie Gao, Yun Mu, Yi-Di Guan, Yu-Mei Duan, Xiu-Ping Zhang, De-Xiang Zhang, Nan Li, Yue-Zhen Deng, Lun-Quan Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Oncology
Subjects:
FTO
ICC
RNA m6A modification
metastasis
TEAD2
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.00369/full

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