Ultrastructural Changes Associated With the Enhanced Permeability of the Round Window Membrane Mediated by Ultrasound Microbubbles

Ultrastructural Changes Associated With the Enhanced Permeability of the Round Window Membrane Mediated by Ultrasound Microbubbles

The round window membrane (RWM) is the most common entryway for local drug and gene delivery into the inner ear, but its permeability can change the treatment outcome. We previously demonstrated a feasible and highly efficient approach using ultrasound-aided microbubble (USMB) cavitation to enhance...

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Bibliographic Details
Main Authors: Yi-Chun Lin, Hsin-Chien Chen, Hang-Kang Chen, Yuan-Yung Lin, Chao-Yin Kuo, Hao Wang, Chia-Lien Hung, Cheng-Ping Shih, Chih-Hung Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Pharmacology
Subjects:
ultrasound
microbubble
round window membrane (RWM)
permeability
inner ear
ultrastructure
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01580/full

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https://www.frontiersin.org/article/10.3389/fphar.2019.01580/full

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