Determination of ionization constants (PKA) of β-hydroxy-β-arylalkanoic acids using high-pressure liquid chromatography

pKa values of five β-hydroxy-β-arylalkanoic acids and ibuprofen were determined using the RP-HPLC method. Stationary phase was octadecyl modified (C-18) silica gel, and mobile phase was a mixture of methanol and one of nine different buffers (60:40, v/v). wspH values were measured after mixing metha...

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Bibliographic Details
Main Authors: Savić Jelena S., Marković Bojan, Vitnik Vesna, Dilber Sanda P.
Format: Article
Language:English
Published: University of Kragujevac, Faculty of Science 2018-01-01
Series:Kragujevac Journal of Science
Subjects:
Online Access:https://scindeks-clanci.ceon.rs/data/pdf/1450-9636/2018/1450-96361840103S.pdf