Reverse optogenetics of G protein signaling by zebrafish non-visual opsin Opn7b for synchronization of neuronal networks

Reverse optogenetics of G protein signaling by zebrafish non-visual opsin Opn7b for synchronization of neuronal networks

Microbial rhodopsins can be used to control action potentials, while animal opsins can be used to control intracellular signaling pathways. The authors identify Opn7b as constitutively active Gi/o coupled receptor that can be deactivated by light and used to modulate neuronal activity.

Bibliographic Details
Main Authors: Raziye Karapinar, Jan Claudius Schwitalla, Dennis Eickelbeck, Johanna Pakusch, Brix Mücher, Michelle Grömmke, Tatjana Surdin, Thomas Knöpfel, Melanie D. Mark, Ida Siveke, Stefan Herlitze
Format: Article
Language:English
Published: Nature Publishing Group 2021-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-24718-0

Internet

https://doi.org/10.1038/s41467-021-24718-0

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