Jarid2 Coordinates Nanog Expression and PCP/Wnt Signaling Required for Efficient ESC Differentiation and Early Embryo Development

Jarid2 Coordinates Nanog Expression and PCP/Wnt Signaling Required for Efficient ESC Differentiation and Early Embryo Development

Jarid2 is part of the Polycomb Repressor complex 2 (PRC2) responsible for genome-wide H3K27me3 deposition. Unlike other PRC2-deficient embryonic stem cells (ESCs), however, Jarid2-deficient ESCs show a severe differentiation block, altered colony morphology, and distinctive patterns of deregulated g...

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Bibliographic Details
Main Authors: David Landeira, Hakan Bagci, Andrzej R. Malinowski, Karen E. Brown, Jorge Soza-Ried, Amelie Feytout, Zoe Webster, Elodie Ndjetehe, Irene Cantone, Helena G. Asenjo, Neil Brockdorff, Thomas Carroll, Matthias Merkenschlager, Amanda G. Fisher
Format: Article
Language:English
Published: Elsevier 2015-07-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715006865

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http://www.sciencedirect.com/science/article/pii/S2211124715006865

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