Akt3-Mediated Protection Against Inflammatory Demyelinating Disease

Akt3-Mediated Protection Against Inflammatory Demyelinating Disease

Akt is a serine/threonine protein kinase that plays a major role in regulating multiple cellular processes. While the isoforms Akt1 and Akt2 are involved in apoptosis and insulin signaling, respectively, the role for Akt3 remains uncertain. Akt3 is predominantly expressed in the brain, and total del...

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Bibliographic Details
Main Authors: Juwen C. DuBois, Alex K. Ray, Ross C. Gruber, Yongwei Zhang, Ranee Aflakpui, Fernando Macian-Juan, Bridget Shafit-Zagardo
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Immunology
Subjects:
Akt3
neuroprotection
neuroinflammation
demyelination
EAE
regulatory T-cells (Tregs)
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01738/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01738/full

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