Reduction of Oxidative Stress Attenuates Lipoapoptosis Exacerbated by Hypoxia in Human Hepatocytes

Reduction of Oxidative Stress Attenuates Lipoapoptosis Exacerbated by Hypoxia in Human Hepatocytes

Chronic intermittent hypoxia, a characteristic of obstructive sleep apnea (OSA), is associated with the progression of simple hepatic steatosis to necroinflammatory hepatitis. We determined whether inhibition of a hypoxia-induced signaling pathway could attenuate hypoxia-exacerbated lipoapoptosis in...

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Bibliographic Details
Main Authors: Sang Youn Hwang, Su Jong Yu, Jeong-Hoon Lee, Hwi Young Kim, Yoon Jun Kim
Format: Article
Language:English
Published: MDPI AG 2015-02-01
Series:International Journal of Molecular Sciences
Subjects:
obstructive sleep apnea
nonalcoholic steatohepatitis
lipoapoptosis
hypoxia
endoplasmic reticulum stress
oxidative stress
Online Access:http://www.mdpi.com/1422-0067/16/2/3323

Internet

http://www.mdpi.com/1422-0067/16/2/3323

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