The modulation of Amyotrophic Lateral Sclerosis risk by Ataxin-2 intermediate polyglutamine expansions is a specific effect

The modulation of Amyotrophic Lateral Sclerosis risk by Ataxin-2 intermediate polyglutamine expansions is a specific effect

Full expansions of the polyglutamine domain (polyQ≥34) within the polysome-associated protein ataxin-2 (ATXN2) are the cause of a multi-system neurodegenerative disorder, which usually presents as a Spino-Cerebellar Ataxia and is therefore known as SCA2, but may rarely manifest as Levodopa-responsiv...

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Bibliographic Details
Main Authors: Suzana Gispert, Alexander Kurz, Stefan Waibel, Peter Bauer, Inga Liepelt, Christof Geisen, Aaron D. Gitler, Tim Becker, Markus Weber, Daniela Berg, Peter M. Andersen, Rejko Krüger, Olaf Riess, Albert C. Ludolph, Georg Auburger
Format: Article
Language:English
Published: Elsevier 2012-01-01
Series:Neurobiology of Disease
Subjects:
Ataxin-2
Ataxin-3
Spinocerebellar Ataxia type 2
Motor neuron disease
Amyotrophic Lateral Sclerosis
Parkinson's disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996111002877

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http://www.sciencedirect.com/science/article/pii/S0969996111002877

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