Major contribution of the RNA-binding domain of NS1 in the pathogenicity and replication potential of an avian H7N1 influenza virus in chickens

Major contribution of the RNA-binding domain of NS1 in the pathogenicity and replication potential of an avian H7N1 influenza virus in chickens

Abstract Background Non-structural protein NS1 of influenza A viruses harbours several determinants of pathogenicity and host-range. However it is still unclear to what extent each of its two structured domains (i.e. RNA-binding domain, RBD, and effector domain, ED) contribute to its various activit...

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Bibliographic Details
Main Authors: Sascha Trapp, Denis Soubieux, Alexandra Lidove, Evelyne Esnault, Adrien Lion, Vanaique Guillory, Alan Wacquiez, Emmanuel Kut, Pascale Quéré, Thibaut Larcher, Mireille Ledevin, Virginie Nadan, Christelle Camus-Bouclainville, Daniel Marc
Format: Article
Language:English
Published: BMC 2018-03-01
Series:Virology Journal
Subjects:
Influenza A
NS1
Viral replication
Chicken
Online Access:http://link.springer.com/article/10.1186/s12985-018-0960-4

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http://link.springer.com/article/10.1186/s12985-018-0960-4

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