DJ-1 suppresses ferroptosis through preserving the activity of S-adenosyl homocysteine hydrolase

DJ-1 suppresses ferroptosis through preserving the activity of S-adenosyl homocysteine hydrolase

DJ-1 protects cells from oxidative stress-induced cell death; however its role in ferroptosis is unclear. Here, the authors show that DJ-1 suppresses ferroptosis through the transsulfuration pathway to compensate for the depletion of intracellular cysteine when cystine import is inhibited.

Bibliographic Details
Main Authors: Ji Cao, Xiaobing Chen, Li Jiang, Bin Lu, Meng Yuan, Difeng Zhu, Hong Zhu, Qiaojun He, Bo Yang, Meidan Ying
Format: Article
Language:English
Published: Nature Publishing Group 2020-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-15109-y

Internet

https://doi.org/10.1038/s41467-020-15109-y

Similar Items