ETV4 promotes late development of prostatic intraepithelial neoplasia and cell proliferation through direct and p53-mediated downregulation of p21

ETV4 promotes late development of prostatic intraepithelial neoplasia and cell proliferation through direct and p53-mediated downregulation of p21

Abstract Background ETV4 is one of the ETS proteins overexpressed in prostate cancer (PC) as a result of recurrent chromosomal translocations. In human prostate cell lines, ETV4 promotes migration, invasion, and proliferation; however, its role in PC has been unclear. In this study, we have explored...

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Bibliographic Details
Main Authors: Irene Cosi, Annamaria Pellecchia, Emanuele De Lorenzo, Eugenio Torre, Michela Sica, Gabriella Nesi, Rosario Notaro, Maria De Angioletti
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Journal of Hematology & Oncology
Subjects:
Prostate cancer
Mouse model
ETV4
ETS proteins
Cell proliferation
Cell cycle
Online Access:http://link.springer.com/article/10.1186/s13045-020-00943-w

Internet

http://link.springer.com/article/10.1186/s13045-020-00943-w

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