Association between circulating alpha-1 antitrypsin polymers and lung and liver disease

Association between circulating alpha-1 antitrypsin polymers and lung and liver disease

Abstract Background Alpha-1 antitrypsin deficiency (AATD) is considered one of the most common genetic diseases and is characterised by the misfolding and polymerisation of the alpha-1 antitrypsin (AAT) protein within hepatocytes. The relevance of circulating polymers (CP) of AAT in the pathogenesis...

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Bibliographic Details
Main Authors: Alexa Núñez, Irene Belmonte, Elena Miranda, Miriam Barrecheguren, Georgina Farago, Eduardo Loeb, Mònica Pons, Francisco Rodríguez-Frías, Pablo Gabriel-Medina, Esther Rodríguez, Joan Genescà, Marc Miravitlles, Cristina Esquinas
Format: Article
Language:English
Published: BMC 2021-09-01
Series:Respiratory Research
Subjects:
Alpha-1 antitrypsin deficiency
Circulating polymers
Emphysema
Liver disease
Online Access:https://doi.org/10.1186/s12931-021-01842-5

Internet

https://doi.org/10.1186/s12931-021-01842-5

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