A Novel Microtubule-Binding Drug Attenuates and Reverses Protein Aggregation in Animal Models of Alzheimer’s Disease

A Novel Microtubule-Binding Drug Attenuates and Reverses Protein Aggregation in Animal Models of Alzheimer’s Disease

Age-progressive neurodegenerative pathologies, including Alzheimer’s disease (AD), are distinguished and diagnosed by disease-specific components of intra- or extra-cellular aggregates. Increasing evidence suggests that neuroinflammation promotes protein aggregation, and is involved in the etiology...

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Bibliographic Details
Main Authors: Samuel Kakraba, Srinivas Ayyadevara, Narsimha Reddy Penthala, Meenakshisundaram Balasubramaniam, Akshatha Ganne, Ling Liu, Ramani Alla, Shoban Babu Bommagani, Steven W. Barger, W. Sue T. Griffin, Peter A. Crooks, Robert J. Shmookler Reis
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Alzheimer’s disease
protein aggregation
GFAP (Glial Fibrillary Acidic Protein)
tubulin
combretastatin
anti-aggregant activity
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2019.00310/full

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https://www.frontiersin.org/article/10.3389/fnmol.2019.00310/full

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