Delivery of Quantum Dot-siRNA Nanoplexes in SK-N-SH Cells for BACE1 Gene Silencing and Intracellular Imaging

Delivery of Quantum Dot-siRNA Nanoplexes in SK-N-SH Cells for BACE1 Gene Silencing and Intracellular Imaging

The fluorescent quantum dots (QDs) delivered small interfering RNAs (siRNAs) targeting β-secretase (BACE1) to achieve high transfection efficiency of siRNAs and reduction of β-amyloid (Aβ) in nerve cells. The CdSe/ZnS QDs with the conjugation of amino-polyethylene glycol (PEG) were synthesized. Nega...

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Bibliographic Details
Main Authors: Shengliang Li, Zhonghua Liu, Fengtao Ji, Zijian Xiao, Minjuan Wang, Yingji Peng, Yulin Zhang, Ling Liu, Zibing Liang, Feng Li
Format: Article
Language:English
Published: Elsevier 2012-01-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
Alzheimer's disease
BACE1
quantum dot
siRNA
SK-N-SH cells
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253116300749

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http://www.sciencedirect.com/science/article/pii/S2162253116300749

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