Toll-like receptor 2 ligand and interferon-γ suppress anti-tumor T cell responses by enhancing the immunosuppressive activity of monocytic myeloid-derived suppressor cells

Toll-like receptor 2 ligand and interferon-γ suppress anti-tumor T cell responses by enhancing the immunosuppressive activity of monocytic myeloid-derived suppressor cells

CD11b+Gr1+ myeloid-derived suppressor cells (MDSCs) suppress activation/proliferation of cytotoxic T cells, thereby hindering cancer immunotherapy. MDSCs are increased after adjuvant therapy with toll-like receptor (TLR) 2 ligands, such as Pam2CSK4, in tumor-bearing mice. However, it remains unknown...

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Bibliographic Details
Main Authors: Hiroaki Shime, Akira Maruyama, Sumito Yoshida, Yohei Takeda, Misako Matsumoto, Tsukasa Seya
Format: Article
Language:English
Published: Taylor & Francis Group 2018-01-01
Series:OncoImmunology
Subjects:
inducible no synthase (inos/nos2)
interferon-γ (ifn-γ)
macrophages
monocytic mdscs (m-mdscs)
myeloid-derived suppressor cells (mdscs)
nitric oxide (no)
toll-like receptor 2 (tlr2)
Online Access:http://dx.doi.org/10.1080/2162402X.2017.1373231

Internet

http://dx.doi.org/10.1080/2162402X.2017.1373231

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