Targeting Transcriptional Regulators of CD8+ T Cell Dysfunction to Boost Anti-Tumor Immunity

Targeting Transcriptional Regulators of CD8+ T Cell Dysfunction to Boost Anti-Tumor Immunity

Transcription is a dynamic process influenced by the cellular environment: healthy, transformed, and otherwise. Genome-wide mRNA expression profiles reflect the collective impact of pathways modulating cell function under different conditions. In this review we focus on the transcriptional pathways...

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Bibliographic Details
Main Authors: Katherine A. Waugh, Sonia M. Leach, Jill E. Slansky
Format: Article
Language:English
Published: MDPI AG 2015-09-01
Series:Vaccines
Subjects:
tumor-infiltrating T cells
TIL
transcriptional regulation
T cell dysfunction
T cell hypofunction
anergy
tolerance
exhaustion
NF-κB
NFAT
PD-1
pathway analysis
transcriptome analysis
cancer immunotherapy
Online Access:http://www.mdpi.com/2076-393X/3/3/771

Internet

http://www.mdpi.com/2076-393X/3/3/771

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