Transplanted Erythropoietin-Expressing Mesenchymal Stem Cells Promote Pro-survival Gene Expression and Protect Photoreceptors From Sodium Iodate-Induced Cytotoxicity in a Retinal Degeneration Model

Transplanted Erythropoietin-Expressing Mesenchymal Stem Cells Promote Pro-survival Gene Expression and Protect Photoreceptors From Sodium Iodate-Induced Cytotoxicity in a Retinal Degeneration Model

Mesenchymal stem cells (MSC) are highly regarded as a potential treatment for retinal degenerative disorders like retinitis pigmentosa and age-related macular degeneration. However, donor cell heterogeneity and inconsistent protocols for transplantation have led to varied outcomes in clinical trials...

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Bibliographic Details
Main Authors: Avin Ee-Hwan Koh, Hiba Amer Alsaeedi, Munirah Binti Abd Rashid, Chenshen Lam, Mohd Hairul Nizam Harun, Min Hwei Ng, Hazlita Mohd Isa, Kong Yong Then, Mae-Lynn Catherine Bastion, Aisha Farhana, Mohammad Khursheed Alam, Suresh Kumar Subbiah, Pooi Ling Mok
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
mesenchymal stem cells
erythropoietin
sodium iodate
transcriptome
photoreceptors
pro-survival genes
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.652017/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.652017/full

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