Do natural Treg become activated to antigen specific Treg in transplantation and in autoimmunity?

Do natural Treg become activated to antigen specific Treg in transplantation and in autoimmunity?

Antigen specific Treg are often CD4+CD25+FoxP3+T cells, with a phenotype similar to natural Treg (nTreg). It is assumed that nTreg cannot develop into an antigen specific Treg as repeated culture with IL-2 and a specific antigen does not increase the capacity or potency of nTreg to promote immune...

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Bibliographic Details
Main Authors: Bruce Milne Hall, giang T Tran, Nirupama eVerma, Karren ePlain, Catherine M Robinson, Masaru eNomura, Suzanne J Hodgkinson
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-08-01
Series:Frontiers in Immunology
Subjects:
Immune Tolerance
antigen specific Treg
nTreg
Th1-like Treg
Th2-like Treg
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00208/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00208/full

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