CITK Loss Inhibits Growth of Group 3 and Group 4 Medulloblastoma Cells and Sensitizes Them to DNA-Damaging Agents

CITK Loss Inhibits Growth of Group 3 and Group 4 Medulloblastoma Cells and Sensitizes Them to DNA-Damaging Agents

<b> </b>Medulloblastoma (MB) is the most common malignant brain tumor in children, and it is classified into four biological subgroups: WNT, Sonic Hedgehog (SHH), Group 3 and Group 4. The current treatment is surgery, followed by irradiation and chemotherapy. Unfortunately, these therapi...

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Bibliographic Details
Main Authors: Gianmarco Pallavicini, Giorgia Iegiani, Gaia Elena Berto, Elisa Calamia, Edoardo Trevisiol, Andrea Veltri, Simona Allis, Ferdinando Di Cunto
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Cancers
Subjects:
medulloblastoma
radiation
cisplatin
tp53
53bp1
genomic instability
double strand break
dbs
hr
Online Access:https://www.mdpi.com/2072-6694/12/3/542

Internet

https://www.mdpi.com/2072-6694/12/3/542

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