Neutralizing Aptamers from Whole-Cell SELEX Inhibit the RET Receptor Tyrosine Kinase

Neutralizing Aptamers from Whole-Cell SELEX Inhibit the RET Receptor Tyrosine Kinase

<p>Targeting large transmembrane molecules, including receptor tyrosine kinases, is a major pharmacological challenge. Specific oligonucleotide ligands (aptamers) can be generated for a variety of targets through the iterative evolution of a random pool of sequences (SELEX). Nuclease-resistant...

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Bibliographic Details
Main Authors: Cerchia Laura, Ducongé Frédéric, Pestourie Carine, Boulay Jocelyne, Aissouni Youssef, Gombert Karine, Tavitian Bertrand, de Franciscis Vittorio, Libri Domenico
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2005-01-01
Series:PLoS Biology
Subjects:
Biotechnology
Cancer Biology
Online Access:http://dx.doi.org/10.1371/journal.pbio.0030123

Internet

http://dx.doi.org/10.1371/journal.pbio.0030123

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