Targeting Aurora A Kinase (AAK) in Platinum-Resistant High Grade Serous Ovarian Cancer

Targeting Aurora A Kinase (AAK) in Platinum-Resistant High Grade Serous Ovarian Cancer

Aurora A kinase (AAK) involved in G2-M transition is functionally involved in centrosome maturation and maintaining an active spindle assembly checkpoint. We tested the hypothesis that in platinum-taxane resistant high grade serous ovarian cancer (HGSOC) inhibition of AAK involved in G2-M transition...

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Bibliographic Details
Main Authors: Ram N. Ganapathi, Eric J. Norris, Ashley P. Sutker, Kaitlin E. Klotz, Mahrukh K. Ganapathi
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Oncology
Subjects:
aurora A kinase
high grade serous ovarian cancer
platinum-resistance
alisertib
BRCA
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.01354/full

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https://www.frontiersin.org/article/10.3389/fonc.2020.01354/full

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