Nanoparticle Mediated Drug Delivery of Rolipram to Tyrosine Kinase B Positive Cells in the Inner Ear with Targeting Peptides and Agonistic Antibodies

Nanoparticle Mediated Drug Delivery of Rolipram to Tyrosine Kinase B Positive Cells in the Inner Ear with Targeting Peptides and Agonistic Antibodies

AimSystemic pharmacotherapies have limitation due to blood-labyrinth barrier, so local delivery via the round window membrane opens a path for effective treatment. Multifunctional nanoparticle (NP) mediated cell specific drug delivery may enhance efficacy and reduce side effects. Different NPs with...

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Bibliographic Details
Main Authors: Rudolf eGlueckert, Christian Oliver Pritz, Soumen eRoy, Jozsef eDudas, Anneliese eSchrott-Fischer
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-05-01
Series:Frontiers in Aging Neuroscience
Subjects:
Apoptosis Regulatory Proteins
Drug Delivery Systems
Rolipram
BDNF
drug delivery carriers
targeted therapy
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnagi.2015.00071/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnagi.2015.00071/full

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