Grainyhead-like 2 (GRHL2) knockout abolishes oral cancer development through reciprocal regulation of the MAP kinase and TGF-β signaling pathways

Grainyhead-like 2 (GRHL2) knockout abolishes oral cancer development through reciprocal regulation of the MAP kinase and TGF-β signaling pathways

Abstract Grainyhead-Like 2 (GRHL2) is an epithelial-specific transcription factor that regulates epithelial morphogenesis and differentiation. Prior studies suggested inverse regulation between GRHL2 and TGF-β in epithelial plasticity and potential carcinogenesis. Here, we report the role of GRHL2 i...

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Bibliographic Details
Main Authors: Wei Chen, Kyung L. Kang, Abdullah Alshaikh, Saaket Varma, Yi-Ling Lin, Ki-Hyuk Shin, Reuben Kim, Cun-Yu Wang, No-Hee Park, Katharina Walentin, Kai M. Schmidt-Ott, Mo K. Kang
Format: Article
Language:English
Published: Nature Publishing Group 2018-05-01
Series:Oncogenesis
Online Access:https://doi.org/10.1038/s41389-018-0047-5

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https://doi.org/10.1038/s41389-018-0047-5

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