Unlike Its Paralog LEDGF/p75, HRP-2 Is Dispensable for MLL-R Leukemogenesis but Important for Leukemic Cell Survival

Unlike Its Paralog LEDGF/p75, HRP-2 Is Dispensable for MLL-R Leukemogenesis but Important for Leukemic Cell Survival

HDGF-related protein 2 (HRP-2) is a member of the Hepatoma-Derived Growth Factor-related protein family that harbors the structured PWWP and Integrase Binding Domain, known to associate with methylated histone tails or cellular and viral proteins, respectively. Interestingly, HRP-2 is a paralog of L...

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Bibliographic Details
Main Authors: Siska Van Belle, Sara El Ashkar, Kateřina Čermáková, Filip Matthijssens, Steven Goossens, Alessandro Canella, Courtney H. Hodges, Frauke Christ, Jan De Rijck, Pieter Van Vlierberghe, Václav Veverka, Zeger Debyser
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Cells
Subjects:
leukemia
molecular cell biology
protein complex
protein-protein interaction
nuclear magnetic resonance (NMR)
animal model
Online Access:https://www.mdpi.com/2073-4409/10/1/192

Internet

https://www.mdpi.com/2073-4409/10/1/192

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