Is There Still Room for Cancer Vaccines at the Era of Checkpoint Inhibitors

Is There Still Room for Cancer Vaccines at the Era of Checkpoint Inhibitors

Checkpoint inhibitor (CPI) blockade is considered to be a revolution in cancer therapy, although most patients (70%–80%) remain resistant to this therapy. It has been hypothesized that only tumors with high mutation rates generate a natural antitumor T cell response, which could be revigorated by th...

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Bibliographic Details
Main Authors: Soumaya Karaki, Marie Anson, Thi Tran, Delphine Giusti, Charlotte Blanc, Stephane Oudard, Eric Tartour
Format: Article
Language:English
Published: MDPI AG 2016-11-01
Series:Vaccines
Subjects:
cancer vaccine
checkpoint inhibitors
immunotherapy
combination therapy
PD-1
PD-L1
CTLA-4
CD40
OX40
Online Access:http://www.mdpi.com/2076-393X/4/4/37

Internet

http://www.mdpi.com/2076-393X/4/4/37

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