Soluble guanylate cyclase α1-deficient mice: a novel murine model for primary open angle glaucoma.

Soluble guanylate cyclase α1-deficient mice: a novel murine model for primary open angle glaucoma.

Primary open angle glaucoma (POAG) is a leading cause of blindness worldwide. The molecular signaling involved in the pathogenesis of POAG remains unknown. Here, we report that mice lacking the α1 subunit of the nitric oxide receptor soluble guanylate cyclase represent a novel and translatable anima...

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Bibliographic Details
Main Authors: Emmanuel S Buys, Yu-Chieh Ko, Clemens Alt, Sarah R Hayton, Alexander Jones, Laurel T Tainsh, Ruiyi Ren, Andrea Giani, Maeva Clerté, Emma Abernathy, Robert E T Tainsh, Dong-Jin Oh, Rajeev Malhotra, Pankaj Arora, Nadine de Waard, Binglan Yu, Raphael Turcotte, Daniel Nathan, Marielle Scherrer-Crosbie, Stephanie J Loomis, Jae H Kang, Charles P Lin, Haiyan Gong, Douglas J Rhee, Peter Brouckaert, Janey L Wiggs, Meredith S Gregory, Louis R Pasquale, Kenneth D Bloch, Bruce R Ksander
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3603933?pdf=render

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http://europepmc.org/articles/PMC3603933?pdf=render

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