Mycobacterium tuberculosis RipA Dampens TLR4-Mediated Host Protective Response Using a Multi-Pronged Approach Involving Autophagy, Apoptosis, Metabolic Repurposing, and Immune Modulation

Mycobacterium tuberculosis RipA Dampens TLR4-Mediated Host Protective Response Using a Multi-Pronged Approach Involving Autophagy, Apoptosis, Metabolic Repurposing, and Immune Modulation

Reductive evolution has endowed Mycobacterium tuberculosis (M. tb) with moonlighting in protein functions. We demonstrate that RipA (Rv1477), a peptidoglycan hydrolase, activates the NFκB signaling pathway and elicits the production of pro-inflammatory cytokines, TNF-α, IL-6, and IL-12, through the...

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Bibliographic Details
Main Authors: Mohd Shariq, Neha Quadir, Neha Sharma, Jasdeep Singh, Javaid A. Sheikh, Mohd Khubaib, Seyed E. Hasnain, Nasreen Z. Ehtesham
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Immunology
Subjects:
autophagy
RipA
peptidoglycan hyrolase
NFkB
TLR4
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.636644/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.636644/full

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