Differentially Regulated Transcription Factors and ABC Transporters in a Mitochondrial Dynamics Mutant Can Alter Azole Susceptibility of Aspergillus fumigatus

Differentially Regulated Transcription Factors and ABC Transporters in a Mitochondrial Dynamics Mutant Can Alter Azole Susceptibility of Aspergillus fumigatus

Azole resistance of the fungal pathogen Aspergillus fumigatus is an emerging problem. To identify novel mechanisms that could mediate azole resistance in A. fumigatus, we analyzed the transcriptome of a mitochondrial fission/fusion mutant that exhibits increased azole tolerance. Approximately 12% of...

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Bibliographic Details
Main Authors: Laura Sturm, Bernadette Geißel, Ronny Martin, Johannes Wagener
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Microbiology
Subjects:
Aspergillus fumigatus
mitochondrial dynamics
azole resistance
efflux pumps
transcription factors
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2020.01017/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2020.01017/full

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