Overactivation of intestinal SREBP2 in mice increases serum cholesterol.

Overactivation of intestinal SREBP2 in mice increases serum cholesterol.

Sterol Response Element Binding Protein 2 (SREBP2) transcription factor is a master regulator of cholesterol homeostasis. Treatment with statins, inhibitors of cholesterol synthesis, activates intestinal SREBP2, which may hinder their cholesterol-lowering effects. Overactivation of SREBP2 in mouse l...

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Bibliographic Details
Main Authors: Ke Ma, Pooja Malhotra, Vinay Soni, Omar Hedroug, Fadi Annaba, Amish Dudeja, Le Shen, Jerrold R Turner, Ekaterina A Khramtsova, Seema Saksena, Pradeep K Dudeja, Ravinder K Gill, Waddah A Alrefai
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3896331?pdf=render

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http://europepmc.org/articles/PMC3896331?pdf=render

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