Mg2+-dependent facilitation and inactivation of L-type Ca2+ channels in guinea pig ventricular myocytes

Mg2+-dependent facilitation and inactivation of L-type Ca2+ channels in guinea pig ventricular myocytes

This study aimed to investigate the intracellular Mg2+ regulation of the L-type Ca2+ channels in guinea pig ventricular myocytes. By adopting the inside-out configuration of the patch clamp technique, single channel currents of the L-type Ca2+ channels were recorded at different intracellular Mg2+ c...

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Bibliographic Details
Main Authors: Meimi Zhao, Rui Feng, Dongxue Shao, Shuyuan Liu, Ming Lei, Hongmei Wang, Xuefei Sun, Feng Guo, Huiyuan Hu, Masaki Kameyama, Liying Hao
Format: Article
Language:English
Published: Elsevier 2015-11-01
Series:Journal of Pharmacological Sciences
Subjects:
Mg2+
Ca2+ channels
Open probability
Open time
Inside-out configuration
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861315001723

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http://www.sciencedirect.com/science/article/pii/S1347861315001723

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