Molecular communication of the membrane insertase YidC with translocase SecYEG affects client proteins

Abstract The membrane insertase YidC inserts newly synthesized proteins by its hydrophobic slide consisting of the two transmembrane (TM) segments TM3 and TM5. Mutations in this part of the protein affect the insertion of the client proteins. We show here that a quintuple mutation, termed YidC-5S, i...

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Bibliographic Details
Main Authors: Anja Steudle, Dirk Spann, Eva Pross, Sri Karthika Shanmugam, Ross E. Dalbey, Andreas Kuhn
Format: Article
Language:English
Published: Nature Publishing Group 2021-02-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-83224-x