The Capacity of Long-Term in Vitro Proliferation of Acute Myeloid Leukemia Cells Supported Only by Exogenous Cytokines Is Associated with a Patient Subset with Adverse Outcome

The Capacity of Long-Term in Vitro Proliferation of Acute Myeloid Leukemia Cells Supported Only by Exogenous Cytokines Is Associated with a Patient Subset with Adverse Outcome

Acute myeloid leukemia (AML) is an aggressive malignancy, which is highly heterogeneous with regard to chemosensitivity and biological features. The AML cell population is organized in a hierarchy that is reflected in the in vitro growth characteristics, with only a minority of cells being able to p...

Full description

Bibliographic Details
Main Authors: Annette K. Brenner, Elise Aasebø, Maria Hernandez-Valladares, Frode Selheim, Frode Berven, Ida-Sofie Grønningsæter, Sushma Bartaula-Brevik, Øystein Bruserud
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:Cancers
Subjects:
acute myeloid leukemia
clonogenic cells
colony formation
cytokines
differentiation
transcription
Online Access:http://www.mdpi.com/2072-6694/11/1/73

Internet

http://www.mdpi.com/2072-6694/11/1/73

Similar Items