Genomic DISC1 Disruption in hiPSCs Alters Wnt Signaling and Neural Cell Fate

Genomic DISC1 Disruption in hiPSCs Alters Wnt Signaling and Neural Cell Fate

Genetic and clinical association studies have identified disrupted in schizophrenia 1 (DISC1) as a candidate risk gene for major mental illness. DISC1 is interrupted by a balanced chr(1;11) translocation in a Scottish family in which the translocation predisposes to psychiatric disorders. We investi...

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Main Authors: Priya Srikanth, Karam Han, Dana G. Callahan, Eugenia Makovkina, Christina R. Muratore, Matthew A. Lalli, Honglin Zhou, Justin D. Boyd, Kenneth S. Kosik, Dennis J. Selkoe, Tracy L. Young-Pearse
Format: Article
Language:English
Published: Elsevier 2015-09-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715008517

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http://www.sciencedirect.com/science/article/pii/S2211124715008517

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