A Comparative Study to Evaluate the Effect of Different Carbohydrates on the Stability of Immunoglobulin G during Lyophilization and Following Storage

A Comparative Study to Evaluate the Effect of Different Carbohydrates on the Stability of Immunoglobulin G during Lyophilization and Following Storage

Background: Although the stabilizing effects of cyclodextrins (CDs) on the liquid protein formulations have been proven, there is no comprehensive data on evaluation of their effects on the lyophilized antibody powders. In this study, the influence of two CD derivatives namely beta-cyclodextrin (βCD...

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Bibliographic Details
Main Author: Homa Faghihi 1, Sara Merrikhihaghi 1, Abdolhosein Ruholamini Najafabadi 1, Vahid Ramezani 2, Soroush Sardari 3, Alireza Vatanara 1 *
Format: Article
Language:English
Published: Tabriz University of Medical Sciences 2016-12-01
Series:Pharmaceutical Sciences
Subjects:
Antibody
Lyophilization
Mannitol
Trehalose
Cyclodextrins
Stability
Online Access:http://journals.tbzmed.ac.ir/PHARM/Abstract/PHARM_4075_20160317105357

Internet

http://journals.tbzmed.ac.ir/PHARM/Abstract/PHARM_4075_20160317105357

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