Histone deacetylase inhibitors modulate KATP subunit transcription in HL-1 cardiomyocytes through effects on cholesterol homeostasis

Histone deacetylase inhibitors modulate KATP subunit transcription in HL-1 cardiomyocytes through effects on cholesterol homeostasis

Histone deacetylase inhibitors (HDIs) are under investigation for the treatment of a number of human health problems. HDIs have proven therapeutic value in refractory cases of cutaneous T-cell lymphoma,. Electrocardiographic ST segment morphological changes associated with HDIs were observed during...

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Bibliographic Details
Main Authors: Naheed eFatima, Devin C Cohen, Gauthaman eSukumar, Tristan M Sissung, James F Schooley, Mark C Haigney, William C Claycomb, Rachel T Cox, Clifton Lee Dalgard, Susan E. Bates, Thomas P Flagg
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-08-01
Series:Frontiers in Pharmacology
Subjects:
Cholesterol
epigenetics
Romidepsin
ABCC9
ABCC8
SREBP
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00168/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00168/full

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