m6A demethylase ALKBH5 inhibits pancreatic cancer tumorigenesis by decreasing WIF-1 RNA methylation and mediating Wnt signaling

m6A demethylase ALKBH5 inhibits pancreatic cancer tumorigenesis by decreasing WIF-1 RNA methylation and mediating Wnt signaling

Abstract Background Pancreatic cancer is one of the most lethal types of cancer with extremely poor diagnosis and prognosis, and chemo-resistance remains a major challenge. The dynamic and reversible N6-methyladenosine (m6A) RNA modification has emerged as a new layer of epigenetic gene regulation....

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Bibliographic Details
Main Authors: Bo Tang, Yihua Yang, Min Kang, Yunshan Wang, Yan Wang, Yin Bi, Songqing He, Fumio Shimamoto
Format: Article
Language:English
Published: BMC 2020-01-01
Series:Molecular Cancer
Subjects:
Pancreatic cancer
m6A methylation
Chemo-resistance
ALKBH5
WIF-1
Wnt
Online Access:https://doi.org/10.1186/s12943-019-1128-6

Internet

https://doi.org/10.1186/s12943-019-1128-6

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