The ARK Assay Is a Sensitive and Versatile Method for the Global Detection of DNA-Protein Crosslinks

Summary: DNA-protein crosslinks (DPCs) are a frequent form of DNA lesion and are strongly inhibitive in diverse DNA transactions. Despite recent developments, the biochemical detection of DPCs remains a limiting factor for the in-depth mechanistic understanding of DPC repair. Here, we develop a sens...

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Bibliographic Details
Main Authors: Qianghua Hu, Naeh Klages-Mundt, Rui Wang, Erica Lynn, Liton Kuma Saha, Huimin Zhang, Mrinal Srivastava, Xi Shen, Yanyan Tian, Hyeung Kim, Yin Ye, Tanya Paull, Shunichi Takeda, Junjie Chen, Lei Li
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124719317243