Optogenetic Monitoring of the Glutathione Redox State in Engineered Human Myocardium

Optogenetic Monitoring of the Glutathione Redox State in Engineered Human Myocardium

Redox signaling affects all aspects of cardiac function and homeostasis. With the development of genetically encoded fluorescent redox sensors, novel tools for the optogenetic investigation of redox signaling have emerged. Here, we sought to develop a human heart muscle model for in-tissue imaging o...

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Bibliographic Details
Main Authors: Irina Trautsch, Eriona Heta, Poh Loong Soong, Elif Levent, Viacheslav O. Nikolaev, Ivan Bogeski, Dörthe M. Katschinski, Manuel Mayr, Wolfram-Hubertus Zimmermann
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Physiology
Subjects:
optogenetics
engineered human myocardium
redox-reporters
stem cells
cardiomyocytes
fibroblasts
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2019.00272/full

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https://www.frontiersin.org/article/10.3389/fphys.2019.00272/full

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