A limited role for p53 in modulating the immediate phenotype of Apc loss in the intestine

<p>Abstract</p> <p>Background</p> <p>p53 is an important tumour suppressor with a known role in the later stages of colorectal cancer, but its relevance to the early stages of neoplastic initiation remains somewhat unclear. Although p53-dependent regulation of Wnt signa...

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Bibliographic Details
Main Authors: Cole Alicia, Marsh Victoria, Meniel Valerie S, Reed Karen R, Sansom Owen J, Clarke Alan R
Format: Article
Language:English
Published: BMC 2008-06-01
Series:BMC Cancer
Online Access:http://www.biomedcentral.com/1471-2407/8/162