Distribution of GNAQ and GNA11 Mutation Signatures in Uveal Melanoma Points to a Light Dependent Mutation Mechanism.

Distribution of GNAQ and GNA11 Mutation Signatures in Uveal Melanoma Points to a Light Dependent Mutation Mechanism.

Uveal melanomas (UM) originate from melanocytes in the interior wall of the eye, namely from the iris, ciliary body and the choroid with marked differences in light exposure (from dark anterior to illuminated posterior). In contrast to UV radiation, focused or converging visible light readily reache...

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Bibliographic Details
Main Authors: Mark J de Lange, Lubna Razzaq, Mieke Versluis, Sven Verlinde, Mehmet Dogrusöz, Stefan Böhringer, Marina Marinkovic, Gregorius P M Luyten, Rob J W de Keizer, Frank R de Gruijl, Martine J Jager, Pieter A van der Velden
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4569098?pdf=render

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http://europepmc.org/articles/PMC4569098?pdf=render

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