Identification and functional study of GATA4 gene regulatory variants in type 2 diabetes mellitus

Identification and functional study of GATA4 gene regulatory variants in type 2 diabetes mellitus

Abstract Background Type 2 diabetes mellitus (T2D) is a common and complex disease. Dysfunction of pancreatic β cells, which cannot release sufficient insulin, plays a central role in T2D. Genetics plays a critical role in T2D etiology. Transcription factor GATA4 is required for the pancreatic devel...

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Bibliographic Details
Main Authors: Liangcai Ding, Mengdi Cai, Lu Chen, Han Yan, Shicheng Lu, Shuchao Pang, Bo Yan
Format: Article
Language:English
Published: BMC 2021-04-01
Series:BMC Endocrine Disorders
Subjects:
Type 2 diabetes mellitus
Genetics
GATA4
Regulatory variants
Online Access:https://doi.org/10.1186/s12902-021-00739-0

Internet

https://doi.org/10.1186/s12902-021-00739-0

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