Up-Regulation of Mitochondrial Antioxidant Superoxide Dismutase Underpins Persistent Cardiac Nutritional-Preconditioning by Long Chain n-3 Polyunsaturated Fatty Acids in the Rat

Up-Regulation of Mitochondrial Antioxidant Superoxide Dismutase Underpins Persistent Cardiac Nutritional-Preconditioning by Long Chain n-3 Polyunsaturated Fatty Acids in the Rat

Reactive oxygen species paradoxically underpin both ischaemia/reperfusion (I/R) damage and ischaemic preconditioning (IPC) cardioprotection. Long-chain omega-3 polyunsaturated fatty acids (LCn-3 PUFA) are highly susceptible to peroxidation, but are paradoxically cardioprotective. This study tested t...

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Bibliographic Details
Main Authors: Grace G. Abdukeyum, Alice J. Owen, Theresa A. Larkin, Peter L. McLennan
Format: Article
Language:English
Published: MDPI AG 2016-03-01
Series:Journal of Clinical Medicine
Subjects:
fish oil
preconditioning
antioxidant
reactive oxygen species
ischaemia
reperfusion
n-3 PUFA
lipid oxidation
infarct
Online Access:http://www.mdpi.com/2077-0383/5/3/32

Internet

http://www.mdpi.com/2077-0383/5/3/32

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