Severe Tuberculosis in Humans Correlates Best with Neutrophil Abundance and Lymphocyte Deficiency and Does Not Correlate with Antigen-Specific CD4 T-Cell Response

Severe Tuberculosis in Humans Correlates Best with Neutrophil Abundance and Lymphocyte Deficiency and Does Not Correlate with Antigen-Specific CD4 T-Cell Response

It is generally thought that Mycobacterium tuberculosis (Mtb)-specific CD4+ Th1 cells producing IFN-γ are essential for protection against tuberculosis (TB). In some studies, protection has recently been associated with polyfunctional subpopulation of Mtb-specific Th1 cells, i.e., with cells able to...

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Bibliographic Details
Main Authors: Alexander V. Panteleev, Irina Yu Nikitina, Irina A. Burmistrova, George A. Kosmiadi, Tatyana V. Radaeva, Rasul B. Amansahedov, Pavel V. Sadikov, Yana V. Serdyuk, Elena E. Larionova, Tatef R. Bagdasarian, Larisa N. Chernousova, Vitaly V. Ganusov, Irina V. Lyadova
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-08-01
Series:Frontiers in Immunology
Subjects:
tuberculosis
Th1 cells
pulmonary destruction
neutrophils
band neutrophils
polyfunctional lymphocytes
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00963/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.00963/full

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