Inhibition of the Schizophrenia-Associated MicroRNA miR-137 Disrupts Nrg1α Neurodevelopmental Signal Transduction

Inhibition of the Schizophrenia-Associated MicroRNA miR-137 Disrupts Nrg1α Neurodevelopmental Signal Transduction

Genomic studies have repeatedly associated variants in the gene encoding the microRNA miR-137 with increased schizophrenia risk. Bioinformatic predictions suggest that miR-137 regulates schizophrenia-associated signaling pathways critical to neural development, but these predictions remain largely u...

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Bibliographic Details
Main Authors: Kristen Therese Thomas, Bart Russell Anderson, Niraj Shah, Stephanie Elaine Zimmer, Daniel Hawkins, Arielle Nicole Valdez, Qiaochu Gu, Gary Jonathan Bassell
Format: Article
Language:English
Published: Elsevier 2017-07-01
Series:Cell Reports
Subjects:
miR-137
neuregulin
BDNF
schizophrenia
mTOR
AMPAR
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717308525

Internet

http://www.sciencedirect.com/science/article/pii/S2211124717308525

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