Pharmacokinetics, Bioavailability, Excretion and Metabolism Studies of Akebia Saponin D in Rats: Causes of the Ultra-Low Oral Bioavailability and Metabolic Pathway

Pharmacokinetics, Bioavailability, Excretion and Metabolism Studies of Akebia Saponin D in Rats: Causes of the Ultra-Low Oral Bioavailability and Metabolic Pathway

Background: Akebia saponin D (ASD) has a variety of biological activities and great medicinal potential, but its oral bioavailability is so low as to limit its development. Its pharmacokinetic profiles and excretion and metabolism in vivo have not been fully elucidated. This study was an attempt in...

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Bibliographic Details
Main Authors: Pengfei Li, Jun Peng, Yuexin Li, Lili Gong, Yali Lv, He Liu, Tianhong Zhang, Song Yang, Hongchuan Liu, Jinglai Li, Lihong Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Pharmacology
Subjects:
Akebia saponin D
pharmacokinetics
bioavailability
metabolism
excretion
LC–MS/MS
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.621003/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.621003/full

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