Propeptide-mediated inhibition of cognate gingipain proteinases.

Propeptide-mediated inhibition of cognate gingipain proteinases.

Porphyromonas gingivalis is a major pathogen associated with chronic periodontitis. The organism's cell-surface cysteine proteinases, the Arg-specific proteinases (RgpA, RgpB) and the Lys-specific proteinase (Kgp), which are known as gingipains have been implicated as major virulence factors. A...

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Bibliographic Details
Main Authors: N Laila Huq, Christine A Seers, Elena C Y Toh, Stuart G Dashper, Nada Slakeski, Lianyi Zhang, Brent R Ward, Vincent Meuric, Dina Chen, Keith J Cross, Eric C Reynolds
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3677877?pdf=render

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http://europepmc.org/articles/PMC3677877?pdf=render

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