Connectivity Map Analysis Indicates PI3K/Akt/mTOR Inhibitors as Potential Anti-Hypoxia Drugs in Neuroblastoma

Connectivity Map Analysis Indicates PI3K/Akt/mTOR Inhibitors as Potential Anti-Hypoxia Drugs in Neuroblastoma

Neuroblastoma (NB) is one of the deadliest pediatric cancers, accounting for 15% of deaths in childhood. Hypoxia is a condition of low oxygen tension occurring in solid tumors and has an unfavorable prognostic factor for NB. In the present study, we aimed to identify novel promising drugs for NB tre...

Full description

Bibliographic Details
Main Authors: Paolo Uva, Maria Carla Bosco, Alessandra Eva, Massimo Conte, Alberto Garaventa, Loredana Amoroso, Davide Cangelosi
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Cancers
Subjects:
neuroblastoma
hypoxia
PI3K/Akt/mTOR inhibitors
treatment
Online Access:https://www.mdpi.com/2072-6694/13/11/2809

Similar Items

Similar Items