β-Amyloid-Induced Inflammation and Cholinergic Hypofunction in the Rat Brain in Vivo: Involvement of the p38MAPK Pathway

β-Amyloid-Induced Inflammation and Cholinergic Hypofunction in the Rat Brain in Vivo: Involvement of the p38MAPK Pathway

Injection into the nucleus basalis of the rat of preaggregated Aβ(1-42) produced a congophylic deposit and microglial and astrocyte activation and infiltration and caused a strong inflammatory reaction characterized by IL-1β production, increased inducible cyclooxygenase (COX-2), and inducible nitri...

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Bibliographic Details
Main Authors: Maria Grazia Giovannini, Carla Scali, Costanza Prosperi, Arianna Bellucci, Maria Giuliana Vannucchi, Susanna Rosi, Giancarlo Pepeu, Fiorella Casamenti
Format: Article
Language:English
Published: Elsevier 2002-11-01
Series:Neurobiology of Disease
Subjects:
MAPK
inflammation
cholinergic hypofunction
Alzheimer's disease
β-amyloid
rofecoxib
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996102905383

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http://www.sciencedirect.com/science/article/pii/S0969996102905383

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