β-Amyloid-Induced Inflammation and Cholinergic Hypofunction in the Rat Brain in Vivo: Involvement of the p38MAPK Pathway
Injection into the nucleus basalis of the rat of preaggregated Aβ(1-42) produced a congophylic deposit and microglial and astrocyte activation and infiltration and caused a strong inflammatory reaction characterized by IL-1β production, increased inducible cyclooxygenase (COX-2), and inducible nitri...
Main Authors: | Maria Grazia Giovannini, Carla Scali, Costanza Prosperi, Arianna Bellucci, Maria Giuliana Vannucchi, Susanna Rosi, Giancarlo Pepeu, Fiorella Casamenti |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2002-11-01
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Series: | Neurobiology of Disease |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996102905383 |
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